Surtos de fotossensibilização e dermatite alérgica em ruminantes e equídeos no Nordeste do Brasil / Outbreaks of photosensitization and allergic dermatitis in ruminants and equidae in northeastern Brazil

O presente estudo foi conduzido com o objetivo de determinar as causas de fotossensibilização em ruminantes e equídeos no Nordeste do Brasil, através da revisão dos laudos de exames arquivados no Laboratório de Patologia Veterinária da Universidade Federal da Paraíba. Durante os quatro anos do estudo foram diagnosticados 22 surtos de fotossensibilização, incluindo 11 surtos de fotossensibilização primária e oito surtos de fotossensibilização hepatógena. A intoxicação por Froelichia humboldtiana foi a principal causa de fotossensibilização e a única causa de fotossensibilização primária. As espécies mais gravemente afetadas por fotossensibilização primária foram os asininos, caprinos, bovinos e ovinos, mas os equinos e mulas também são afetados. A intoxicação por Brachiaria decumbens foi a principal causa de fotossensibilização hepatógena e afetou apenas os ovinos e bovinos. Outras plantas associadas com fotossensibilização hepatógena incluíram Enterolobium contortisiliquum e Lantana camara. Dermatite alérgica foi diagnosticada em dois rebanhos ovinos e em um cavalo. Os animais tinham lesões crônicas, caracterizadas por alopecia, crostas e hiperpigmentação no topo da cabeça, ao redor dos olhos (ovinos) e nos membros (equino). O prurido foi o principal sinal clínico observado nos casos de fotossensibilização primária e hipersensibilidade à picada de insetos.(AU)

The study was conducted to determine the causes of photosensitization in ruminants and equidae in northeastern Brazil through a review of the files at the Laboratório de Patologia Veterinária of Universidade Federal da Paraíba. During four years of the study 22 outbreaks of photosensitization were diagnosed, including 11 outbreaks of primary photosensitization and eight outbreaks of hepatogenous photosensitization. Poisoning by Froelichia humboldtiana was the main cause of photosensitization, and the only cause of primary photosensitization. The most severely affected animals by primary photosensitization are donkeys, goats, cattle and sheep, but horses and mules may also be affected. Poisoning by Brachiaria decumbens was the main cause of hepatogenous photosensitization, and affected only sheep and cattle. Other plants associated with hepatogenous photosensitization in cattle include Enterolobium contortisiliquum and Lantana camara. Allergic dermatitis was diagnosed in two flocks of sheep and in a horse. The animals had chronic lesions characterized by areas of alopecia, crusts and hyperpigmentation on the head, around the eyes (sheep) and at the legs (horse). Itching was the main clinical sign in cases of primary photosensitization and insect hypersensitivity.(AU)

Advances on treatment of allergic disease by isoflavonic phytoestrogens / 中国药理学通报

Isoflavone phytoestrogen,which is one of the biologi-cal flavonoids, has effect on immune system. Previous research has demonstrated that isoflavone phytoestrogens improve allergic symptom via sustaining Th1/Th2 balance, regulating immune cells and increasing the host on the food of the trigger tolerance effects. This review provides information for the effect of isofla-vone phytoestrogens on allergic disease and its mechanism, ho-ping to promote its research and utilization.

Caracterización de la Dermatitis ocupacional en pacientes evaluados en consulta de Dermatología / Characterization of the occupational Dermatitis in patients evaluated in consultation of Dermatology

Introducción: La Dermatitis ocupacional es una inflamación de la piel provocada por el entorno laboral o contacto de una sustancia perjudicial, siendo considerada el problema de salud más frecuente en el ámbito laboral. Objetivo: Describir las características de los pacientes con Dermatitis ocupacional atendidos en una consulta de Dermatología durante 2015. Material y Métodos: Se realizó una investigación descriptiva transversal con una muestra de 56 personas diagnosticadas con esta enfermedad y que acudieron a consulta de Dermatología del Policlinico Pedro Fonseca durante todo 2015. Resultados: El 58,9 por ciento fue del sexo femenino, quienes llevaban más de 5 años de trabajo e iniciaron los síntomas más de 12 meses antes. El 100 por ciento de los pacientes tenían lesiones eritematosas y 94,6 por ciento presentaron liquenificación. La presentación de las lesiones costrosas fue de 69,6 por ciento más evidente en manos y muñecas. Conclusiones: Los pacientes con diagnóstico de Dermatitis ocupacional fueron los más frecuentes en la consulta de Dermatología de nuestra área de salud durante 2015. La Dermatitis ocupacional atópica superó en número de casos diagnosticados y en severidad de las lesiones a la Dermatitis ocupacional irritativa, siendo además la de mayor tiempo de evolución de los síntomas(AU)

Introduction: The occupational Dermatitis is an inflammation of the skin caused by the labor environment or contact of a harmful substance, being considered the more frequent health problem in the labor environment. Objective: To describe the characteristics of the patients with occupational Dermatitis assisted in a consultation of Dermatology during 2015. Material and Methods: He/she was carried out a traverse descriptive investigation with a sample of 56 people diagnosed with this illness and that they went to consultation of Dermatology of the Policlinic Pedro Fonseca during everything 2015. Results: 58,9 percent was of the feminine sex who had more than 5 years of work and they began the symptoms before more than 12 months. 100 percent of the patients had erythematous lesions and 94,6 percent of them presented lichenification. The presentation of the scabby lesions was of 69,6 more evident percent in hands and risks. Conclusions: The patients with diagnostic of occupational Dermatitis were the most frequent in the consultation of Dermatology of our health area during 2015. The atopic occupational Dermatitis overcame in number of diagnosed cases and in severity of the lesions to the occupational irritating Dermatitis, being also the one with the bigger time of evolution of the symptoms(AU)

Allergic dermatitis caused by Culicoides in Texel sheep in the state of Pará, Brazil / Dermatite alérgica causada por Culicoides em ovinos Texel no estado do Pará

Allergic dermatitis was studied at a farm located in the municipality of Castanhal in the state of Pará, Brazil, from December 2009 to December 2012. Clinical and epidemiological data were obtained during monthly visits to the farm. Skin biopsies were performed for histopathological examinations, and insects were captured with Centers for Disease Control and Prevention (CDC) traps and live-bait entomological vacuum devices. The property housed a herd of both genders, with 45 Santa Inês sheep of different ages and 72 Texel adults. Of the 72 Texel sheep, 56 were affected. Of these, 24 exhibited alopecia, erythema, edema, and crust in the ears, on top of the head, and less often, around the eyes. In addition to the lesions described above, 14 animals exhibited hyperpigmentation of the ears and/or around the eyes and crust in the nose. Another 18 animals exhibited chronic lesions characterized by deformed and thickened ears, alopecia with hyperpigmentation, and in most cases, secondary bacterial infections with abscesses and/or myiasis. Some of these animals had lost part of their ears. Histologically, the lesions were characterized as orthokeratotic hyperkeratosis, acanthosis, vacuolization, and necrosis of epidermal cells. An inflammatory infiltrate was present in the dermis, which was composed mainly of eosinophils and macrophages, some lymphocytes and mast cells, and few neutrophils, in addition to edema and collagen deposition. The Santa Inês sheep were not affected. Among the captured insects, 294 specimens of Culicoides (Hoffmania) plaumanni Spinelli, 57 specimens of C. (Hoffmania) insignis Lutz, and 27 specimens of other Culicoides species were identified. We conclude that C. plaumanni, C. insignis, and possibly other Culicoides species are involved in the etiology of allergic dermatitis in Texel sheep in the state of Pará. Santa Inês sheep in the same region and under the same conditions were not affected, which suggests lower susceptibility of these animals.(AU)

A doença foi estudada em uma propriedade localizada no município de Castanhal, Pará, no período de dezembro de 2009 a dezembro de 2012. A propriedade possuía um plantel de 117 ovinos, 45 da raça Santa Inês e 72 Texel. Dos 72 ovinos da raça Texel, 56 estavam afetados. Os principais sinais clínicos observados foram alopecia, eritema, edema, hiperpigmentação e crostas nas orelhas, parte superior da cabeça e ao redor dos olhos. Em alguns animais as orelhas estavam deformadas, espessadas e com abscessos e/ou miíase. Histologicamente, as lesões caracterizavam-se por hiperqueratose ortoqueratótica, acantose, vacuolização e necrose das células da epiderme. Na derme havia infiltrado inflamatório composto principalmente por eosinófilos e macrófagos, edema e deposição de colágeno. Entre os insetos capturados foram identificados 294 exemplares de Culicoides (Hoffmania) plaumanni Spinelli, 57 de Culicoides (Hoffmania) insignis Lutz e 27 exemplares pertencentes a outras espécies de Culicoides. Conclui-se que C. plaumanni, C. insignis e, possivelmente, outras espécies de Culicoides estejam envolvidos na etiologia da dermatite alérgica nos ovinos da raça Texel no estado do Pará. Ovinos da raça Santa Inês que se encontravam na mesma área e nas mesmas condições não foram afetados, sugerindo menor susceptibilidade.(AU)

El problema médico legal de las dermatosis ocupacionales / The legal medical problem of occupational dermatoses

Resumen:La dermatosis profesional es aquella alteración dermatológica que se ve originada o empeorada por las condiciones de trabajo. Los estudios comparativos entre países se ven limitados por las diferencias existentes en la notificación de enfermedades profesionales, siendo muchas veces su incidencia subestimada a pesar de ser de gran impacto socioeconómico, pues éstas son una causa frecuente de incapacidad y/o discapacidad relacionada con el trabajo, pudiendo constituir un porcentaje importante de las indemnizaciones económicas en muchas naciones. Es difícil establecer la relación de causalidad entre las dermatosis y una profesión o actividad laboral específica sin disponer de parámetros objetivos, por lo que este artículo busca dar un amplio panorama de cómo abordar el problema médico legal de las dermatosis ocupacionales en las pericias diarias de un médico legista.

Abstract:The professional dermatosis is a dermatological alteration that is originated or worsened by conditions of work. The comparative studies among different countries are limited by the differences in the notification system of occupational diseases, in such a manner that is often underestimated even though they have a socioeconomic impact. In the case of the occupational dermatosis, in many countries they constitute an important percentage of the economic indemnifications, and also a frequent reason of disability related to the job itself. Being able to establish a relation of causality between the dermatosis and a profession or specific labor activity without having objective parameters is most of the time difficult, so that this article seeks to give a wide panorama of how to approach the medical legal problem of the occupational dermatosis in the daily expertise of a forensic doctor.

Investigation on health status of workers exposed to 7-ACA and 6-APA in an antibiotic enterprise / 中国职业医学

OBJECTIVE: To investigate the health status of workers exposed to 7-aminocephalosporanic acid( 7-ACA) and6-aminopenicillanic acid( 6-APA) in an antibiotics enterprise. METHODS: Using simple random sampling method,207 workers exposed to 7-ACA and 6-APA from an antibiotic production enterprise were selected as the exposed group,and 162 workers with no dust exposure history from the same antibiotic production enterprise were selected as control group. Health examinations were performed. The health status of the workers were analyzed. RESULTS: The detection of symptoms( chest distress,shortness of breath,cough,wheezing,itchy skin) and allergic diseases( bronchial asthma,allergic rhinitis,allergic dermatitis) in exposed group were higher than those in control group( P < 0. 05). The lung function indexes such as forced vital capacity( FVC),forced expiratory volume in first second( FEV1) and FEV1/ FVC in the exposed group were lower than those in control group( P < 0. 05). There was no significant difference in the lung function indexes,respiratory and skin allergy symptoms,and allergic diseases between 7-ACA subgroup and 6-APA subgroup( P < 0. 017).The incidence of bronchial asthma,allergic rhinitis had statistical differences in the length of dust exposure in service workers( P < 0. 05). CONCLUSION: Workers exposed to 7-ACA and 6-APA have a high occurrence rate of respiratory symptoms. These workers also suffered from occupational diseases such as bronchial asthma,allergic rhinitis and others.

Pharmacokinetic study on cimifugin in rats / 中国药理学通报

Aim To establish a HPLC method for de-termining cimifugin in rat plasma and investigate the pharmacokinetic characteristics of cimifugin in rats. Methods The plasma concentration of cimifugin was detected by HPLC in acetonitrile protein precipitation method after intragastric administration of cimifugin. The pharmacokinetic parameters were calculated by the procedure of DAS 2 . 1 . Results The regression equa-tion of cimifugin in rats plasma was Y =0. 187 X -0. 0236 (R2 =0. 998 2),which shows a good linear re-lation at 1 - 70 mg · L-1 . The concentration-time curves conformed to two-compartment model. The main pharmacokinetic parameters of Tmax, Cmax, T1/2α, T1/2z, Vd ,AUC(0-t) and AUC(0-∞) were 80 min, 10. 359 mg ·L-1 , 93. 131 min, 2. 179 L · kg-1 , 1946. 085 mg ·L-1 · min, 2138. 57 mg · L-1 · min, respectively. Conclusions We established a HPLC method to de-termine the concentration of cimifugin in plasma. The method is so highly specified and sensitive that it can be used in quantitative analysis in vivo on cimifugin. Cimifugin can be rapidly absorbed, reach the highest concentration and produce effect.

Dermatite alérgica sazonal em ovinos deslanados no nordeste do Brasil / Sazonal allergic dermatitis in hair sheep from northeastern Brazil

Dermatite alérgica sazonal foi diagnosticada em um rebanho de 40 ovinos da raça Santa Inês no município de Jucurutú, Estado de Rio Grande do Norte. Para o estudo epidemiológico e observação dos sinais clínicos a propriedade foi visitada periodicamente entre 2007 e 2010. Os ovinos eram criados extensivamente em campo nativo cortado pelo rio Piranhas e com um açude permanente. Entre 2007 e 2009 adoeceram 13 (32,5%) ovinos de um total de 40. As lesões eram observadas durante a época da chuva e regrediam total ou parcialmente durante a seca, reaparecendo no próximo período chuvoso. Os animais que foram retirados da área se recuperaram. No final de 2009 foram eliminados os animais susceptíveis e três novos casos apareceram em 2010. A pele apresentava lesões alopécicas, crostosas, enrugadas, esbranquiçadas e com intenso prurido, localizados na região da cabeça (orelhas, ao redor dos olhos e região frontal), região dorsal do corpo e garupa. Histologicamente, a epiderme apresentou hiperqueratose, acantose, hipergranulose e moderada espongiose. Na derme havia infiltrado inflamatório, principalmente perivascular, composto por eosinófilos, macrófagos e plasmócitos. Observou-se queratose de folículos pilosos e dilatação das glândulas sudoríparas. No hemograma, os valores de todos os animais estavam dentro dos valores normais. Em abril e junho de 2010 foram realizadas capturas de insetos com armadilhas luminosas CDC, sendo 110 dípteros capturados, dos quais 43 foram identificados como Culicoides insignis Lutz. Considerando que esta espécie tem sido associada à dermatite alérgica em outras regiões conclui-se que a doença é uma dermatite alérgica sazonal associada à picada de C. insignis.

Seasonal allergic dermatitis is reported in a flock of 40 hair sheep of the Santa Inês breed, in the county of Jucurutú, State of Rio Grande do Norte, in the semiarid region of Northeastern Brazil. For the epidemiologic and clinical observations the farm was visited periodically from 2007 to 2010. The flock was raised extensively in a Paddock crossed by the Piranhas river, and had also a permanent pond. Between 2007 and 2009, 13 (32.5%) sheep out of 40 were affected. The lesions were observed during the raining season, regressed total or partially during the dry season, and reappeared in the next raining period. Sheep removed to other region recovered. At the end of 2009, all affected sheep were removed from the flock. Three new cases appeared in 2010. The skin of the affected sheep was whitish, irregularly thickened, with alopecia, crusts, and intense pruritus. Those lesions were localized more frequently in the head (ears and periocular and frontal regions) but in some animals the dorsum and croup were also affected. Histologic lesions of the epidermis were hyperkeratosis, acanthosis, hypergranulosis, and moderate spongiosis. The dermis showed infiltration by eosinophils, macrophages and plasma cells, mainly perivascular. The hair follicles showed keratosis and the sudoriparous glands were dilated. No changes were observed in the differential blood count. In April and June 2010 insects were captured by the use of CDC light trap. Forty three out of 110 dipterous captured were identified as Culicoides insignis Lutz. It is concluded that the disease is a seasonal allergic dermatitis associated with C. insignis bites.

Dermatite de contato alérgica: prevalência dos agentes sensibilizantes em amostra de Porto Alegre, Brasil / Allergic contact dermatitis: prevalence of sensitizing agents in a sample of Porto Alegre, Brazil

Introdução: A Dermatite de Contato Alérgica (DCA) é uma dermatose frequente, tendo grande impacto individual e coletivo na sociedade. Os testes de contato confirmam o diagnóstico e determinam o agente responsável, sendo o método mais eficiente para este fim. Esse estudo objetiva identificar os agentes sensibilizantes mais comuns em pacientes com dermatite alérgica de contato e estudar as características de uma amostra sul-rio-grandense. Métodos: Realizou-se um estudo transversal, com uma população de pacientes avaliados no Serviço de Dermatologia da UFCSPA, entre novembro de 2007 e outubro de 2010, com hipótese diagnóstica de dermatite alérgica de contato, que foram submetidos a testes de contato. Resultados: Incluídos 133 pacientes, com idade média de 42 ± 15, sendo 69,2% do sexo feminino. A atividade ocupacional mais referida foi relacionada à área da limpeza (33,8%). As localizações mais freqüentes da dermatite foram as regiões da cabeça e pescoço (48,9%) e as mãos (45,1%). Os sensibilizantes mais prevalentes foram o sulfato de níquel (33,8%), o thimerosal (18,8%), a parafenilenodiamina (16,5%) e a neomicina (14,3%). Os testes foram considerados relevantes em 75,6% dos testes positivos. Conclusões: Os achados deste estudo coincidiram com os resultados de outros estudos brasileiros, utilizando a bateria padrão de testes de contato, os quais verificaram como principais sensibilizantes agentes encontrados em objetos e utensílios do cotidiano pessoal e ocupacional (metais, tinturas, medicamentos, borracha), com predomínio no sexo feminino. Concluimos também que o teste de contato é uma ferramenta muito útil para diagnóstico e manejo de pacientes com dermatite de contato.

Introduction: Allergic Contact Dermatitis (ACD) is a common skin disorder, with great individual and collective impact on society. Contact tests confirm the diagnosis and determine the causative agent, being the most efficient method for this purpose. This study aims to identify the most common sensitizing agents in patients with allergic contact dermatitis and study the characteristics of a sample from Rio Grande do Sul. Methods: A cross-sectional study with a population of patients evaluated at the Dermatology Service of UFCSPA from Nov 2007 to Oct 2010 with the diagnostic hypothesis of allergic contact dermatitis, who were submitted to a contact test. Results: The study comprised 133 patients, mean age 42 ± 15, 69.2% females. The most often reported occupational activity was related to cleaning jobs (33.8%). The most frequent sites of dermatitis were the head and neck (48.9%) and hands (45.1%). The most prevalent sensitizers were nickel sulfate (33.8%), thimerosal (18.8%), para-phenylenediamine (16.5%), and neomycin (14.3%). The tests were considered relevant in 75.6% of the positive tests. Conclusions: Our findings are in agreement with those of other studies in Brazil, using the standard battery of contact tests, which found the main sensitizing agents present in everyday personal and occupational objects and utensils (metals, dyes, pharmaceuticals, rubber), with predominance in females. We also concluded that the contact test is a very useful tool for diagnosis and management of patients with contact dermatitis.

Dermatite alérgica à picada de insetos em ovinos no estado do Pará / Allergic dermatitis to insect bites in sheep in the state of Pará

Foi estudada uma doença em 159 ovinos em 15 propriedades localizadas em sete municípios das mesorregiões nordeste e sudeste do estado do Pará e uma em um município do estado de Roraima. Os ovinos da raça Santa Inês e seus mestiços, de ambos os sexos e com dois a quatro anos de idade, eram os mais acometidos. A doença caracterizava-se por alopecia em diversas regiões do corpo, principalmente ao redor dos olhos; essas lesões evoluíam para eritemas multifocais, pequenas pápulas e crostas. Os animais apresentavam prurido intenso no local das lesões, inquietação, perda de peso e corrimento ocular. Sempre era observada a presença de mosquitos ao redor dos animais. Com o auxílio de um puçá foi realizada a captura de insetos associados às lesões, durante o repasto nos ovinos, para a identificação. Foram identificados insetos dos gêneros Simulium e Hippelates. Realizou-se biópsia da pele lesada de 10 ovinos. As lesões histológicas se caracterizaram por leves infiltrados inflamatórios mononucleares na derme, com presença de eosinófilos. Os estudos epidemiológicos, clínicos e patológicos desses casos, bem como o descarte dos diagnósticos diferenciais, permitiram concluir que se trata de dermatite alérgica por picada de insetos.

A skin disease was studied in 159 sheep on 15 farms located in seven counties of northeastern and southeastern of the state of Pará and in one farm in the state of Roraima, Brazil. The disease affected mainly two to four year-old sheep of the Santa Ines breed and crossbreds. Clinical signs were characterized by alopecia, multifocal erythema, small papules, and crusts in several areas of the body, mainly around the eyes. Severe itching in the affected areas, restless, weight loss and lacrimation were also observed. Insects were always seen around the animals. Insects apparently associated with the lesions were captured and identified as pertaining to the genera Simulium and Hippelates. Biopsies of the skin lesions of 10 sheep revealed inflammatory non suppurative mononuclear infiltrates of the dermis with presence of eosinophils. The epidemiologic, clinical and pathological studies of the cases allowed the diagnosis of allergic dermatitis due to the insect bites.

Investigation of Correlation between the Form Stigmata of Maximus Thenar Dermatoglyphic Patterns of Palm and Allergic Dermatitis / 中国中医药信息杂志

Objective To discuss the correlation of the form stigmata of maximus thenar dermatoglyphic patterns of palm and allergic dermatitis. Methods The allergic dermatitis patients were rardanly selected as observation group and normal person or non-suffering allergic dermatitis as control group. The maximus thenar dermatoglyphic patterns of palm were classified into three grades on the basis of its tend towards, distance, depth and character of cleavage lines, and the degree of moistening, dryness, softness, smoothness of surface skin, etc. Results There are 82 examples in observation group, grade Ⅰ is 11 examples, degree Ⅰ of grade Ⅱ is 17 examples, degree Ⅱ of grade Ⅱ is 31 examples, grade Ⅲ is 23 examples. There are 86 examples in control group, grade Ⅰ is 71 examples, degree Ⅰ of grade Ⅱ is 5 examples, degree Ⅱ of grade Ⅱ is 6 examples, grade Ⅲ is 4 examples. There is significant difference between the observation group and control group (P

Literature Analysis of 1 Case of Allergic Dermatitis Induced by Meropenem / 中国药房

OBJECTIVE:To study the general regularity and characteristics of adverse drug reaction caused by meropenem,and to provide reference for rational use of drugs.METHODS:Vesicle and bullous change occurring in one patient with allergic dermatitis,age of 80,treated with meropenem were analyzed.Literatures about meropenem-induced ADR reported in domestic pharmaceutical journals from Jan.1994 to Dec.2009 were collected and analyzed statistically.RESULTS:Meropenem rarely caused ADR.The most clinical manifestations were diarrhea,rash and abnormality of liver function.CONCLUSION:Meropenem-induced ADR case is rare as well as allergic dermatitis.Great importance should be attached to meropenem-induced ADR.

To study allergic dermatitis of in-patients at the Department of Allergology and Clinical Immunology in Bach Mai Hospital (1999-2003)

There were 52 patients (30 females and 22 males) suffered from allergic dermatitis admitted to at the Department of Allergology and Clinical Immunology in Bach Mai Hospital (1999-2003). The results showed that: Antibiotic use is main cause of alergic dermatitis, in which phenicol class related to most cases. There were 4 main symptoms of allergic dermatitis: itching, erythema, oedema and vesicle. Symptoms always happened lately. Glucocorticoids, antihistamins and vitamin C are main medications to treat patients with allergic dermatitis.

A Case of Allergic Dermatitis Due to Orthopedic Implant / 대한피부과학회지

The most common form of allergic dermatitis due to orthopedic implant is persistent eczematous reaction. We present an allergic dermatitis occurring in the right upper arm of 77-year-old man who presented an erythematous edematous patch & plaque on the right upper arm after humerus osteosynthesis with orthopedic implant. The lesion disappeared after the removal of the orthopedic implant.

Study on the eddects of "Tru ngua B" tablets in the model of allergic contact dermatitis

“Antiitchy B” tablets were processed from herbal medicines including prepared Rchmannia glutinosa, Angelica sinensis, Paeonia lactiflora, Salvia miltiorrhiza, Glycyrrhiza uralensis, and Sophora flavescens, plus shells of Ostrea gigas and Ketotifen. Experimental study carried on mice with allergic contact dermatitis showed that “antiitchy B” tablets significantly inhibited dinitrofluobenzene induced allergic inflammation in mice ears epidermis

Drug induced allergic dermatitis in Bach Mai hospital

A study on the clinical and paraclinical features and treatment of 95 patients with the drug induced allergic dermatitis has shown that the most common cause of drug induced allergic dermatitis was traditional medication. The disease occurred mainly in people with ages of 15-45. The induced allergic dermatitis occurred lately and subacute. 3 common symptoms were itching, erythematosus and local edema. There were no significant changes of blood biochemistry, the reaction of mastocyte catalysis only supported for the diagnosis.

Study on eficacy and safety of fucicort in the treatment of allergic dermatitis

A study on 35 patients with the allergic dermatitis, ages of 41.23 treated in Friendship hospital during 5-7/2000 has shown that fucicort had a good effect in the first week and best in the second week. There was no adverse effects found. Patients tolerated well the drug.